Gao Wei
Innovation Center for AI and Drug Discovery, East China Normal University
wgao@hsc.ecnu.edu.cn
EDUCATION
2005 – 2010: Ph.D., School of Biological Sciences, The University of Hong Kong.
2000 – 2003: M.Sc., Microbiology, Nankai University, Tianjin, China.
1996 – 2000: B.Sc., Bioengineering, Tianjin University of Science & Technology, China.
WORKING EXPERIENCE
2022 – present: Associate Professor, Innovation Center for AI and Drug Discovery, East China Normal University
2021 – 2022: Research Fellow, Kobilka Institute of Innovative Drug Discovery, Chinese University of Hong Kong
2016 – 2021: Research Assistant Professor, Department of Surgery, Faculty of Medicine, The University of Hong Kong.
2011 – 2016: Postdoctoral Fellow, Department of Surgery, Faculty of Medicine, The University of Hong Kong.
RESEARCH INTERESTS
o Structure and function of G protein-coupled receptors (GPCRs).
o Structure-based drug discovery for GPCRs.
EDITORIAL DUTIES & PROFESSIONAL MEMBERSHIPS
Review editor, Frontiers in Oncology, Frontiers Media S.A., Switzerland.
Member, China anti-cancer association, China.
Member, American Association for Cancer Research, United States.
PEER REVIEW ACTIVITIES
Journal for Oto-Rhino-Laryngology, Head and Neck Surgery
Frontiers in Oncology
Frontiers in Genetics
PLOS ONE
Pathology - Research and Practice
RESEARCH GRANTS (Principle Investigator)
1. Shanghai Pujiang Program (#22PJD023)
Project title: Development of GPR34 antagonists for cancer treatment
Award: RMB300,000 Funding period: 2022 – 2024
2. Health and Medical Research Fund - Full Grant (#06171936, Hong Kong)
Project title: The role of GFPT2 in head and neck squamous cell carcinoma
Award: HK$1,426,240 Funding period: 2019 – 2022
3. National Natural Science Foundation of China (#81773136)
Project title: DHODH enhances metastasis of oral cancer by up-regulating the expression of HIF-1
Award: RMB500,000 Funding period: 2018 – 2021
4. S.K. Yee Medical Foundation Grant (#2161219, Hong Kong)
Project title: Determination of human papillomavirus status in head and neck cancer
Award: HK$542,000 Funding period: 2017 – 2019
5. S.K. Yee Medical Foundation Grant (#2141221, Hong Kong)
Project title: Radiochemotherapy sensitivity test on throat cancer
Award: HK$485,099 Funding period: 2015 – 2017
PUBLICATIONS
1. Wong TS*, Gao W*#, Chen G, Qiu C, He G, Ye F, Wu Z, Zeng Z, Du Y. Cryo-EM structure of orphan G protein-coupled receptor GPR21. MedComm (2020). 2023 Jan 25;4(1):e205. *Equal contributors; #Corresponding author
2. Ye F, Wong TS, Chen G, Zhang Z, Zhang B, Gan S, Gao W, Li J, Wu Z, Pan X, Du Y. Cryo-EM structure of G-protein-coupled receptor GPR17 in complex with inhibitory G protein. MedComm (2020). 2022 Sep 10;3(4):e159.
3. Gao W, Hu L, Zhang M, Liu S, Xu S, Chow VL, Chan JY, Wong TS. Mitochondrial DHODH regulates hypoxia-inducible factor 1 expression in OTSCC. Am J Cancer Res. 2022 Jan 15;12(1):48-67
4. Gao W, Xu S, Zhang M, Liu S, Siu SP, Peng H, Ng JC, Tsao GS, Chan AW, Chow VL, Chan JY, Wong TS. NADPH oxidase 5α promotes the formation of CD271 tumor-initiating cells in oral cancer. Am J Cancer Res. 2020 Jun 1;10(6):1710-1727.
5. Zhang M*, Gao W*, Liu S, Siu SP, Yin M, Ng JC, Chow VL, Chan JY, Wong TS. CD38 triggers inflammasome-mediated pyroptotic cell death in head and neck squamous cell carcinoma. Am J Cancer Res. 2020 Sep 1;10(9):2895-2908. *Equal contributors
6. Gao W, Li JZ, Chen SQ, Chan JY, Yin M, Zhang MJ, Wong TS. Epstein-Barr virus encoded microRNA BART7 regulates radiation sensitivity of nasopharyngeal carcinoma. Oncotarget. 2017 Mar;8(12):20297-20308.
7. Wong TS, Li JZ, Chen SQ, Chan JY, Gao W*. The Efficacy of Triamcinolone Acetonide in Keloid Treatment: A Systematic Review and Meta-analysis. Front Med (Lausanne). 2016;3:71. *Corresponding author
8. Gao W, Li JZ, Chen SQ, Chu CY, Chan JY, Wong TS. Decreased brain-expressed X-linked 4 (BEX4) expression promotes growth of oral squamous cell carcinoma. J Exp Clin Cancer Res. 2016 Jun;35(1):92.
9. Wei FQ, Sun W, Wong TS, Gao W, Wen YH, Wei JW, Wei Y, Wen WP. Eliciting cytotoxic T lymphocytes against human laryngeal cancer-derived antigens: evaluation of dendritic cells pulsed with a heat-treated tumor lysate and other antigen-loading strategies for dendritic-cell-based vaccination. J Exp Clin Cancer Res. 2016 Jan;35(1):18.
10. Gao W, Shi Y, Liu W, Lin WY, Wu JC, Chan JY, Wong TS. Diagnostic value of methylated human telomerase reverse transcriptase in human cancers: A meta-analysis. Front Oncol. 2015;5:296.
11. Gao W, Chan JY, Wong TS. Curcumin exerts inhibitory effects on undifferentiated nasopharyngeal carcinoma by inhibiting the expression of miR-125a-5p. Clin Sci (Lond). 2014 Nov;127(9):571-9.