Title: Zijiang Young Scholar
Department:Health Science Center
Academic Degree:Ph.D.
Graduate School:Fudan University
Email: kzhu@hsc.ecnu.edu.cn
Address:Room 318, Experimental Building A, Health Science Center
Brief Biography: Dr. Kang Zhu is a Zijiang Young Scholar working at the Health Science Center, East China Normal University (ECNU). He completed his postdoctoral training at the Sir William Dunn School of Pathology, University of Oxford (2018-2024) after earning his PhD degree from the Institutes of Biomedical Sciences (IBS) of Fudan University. His research findings have been published in Nulceic Acids Research, PNAS, Science Advances, EMBO Reports, and other journals. His primary research interest is in uncovering the molecular mechanisms of protein post-translational modifications (PTMs) and their connection to disease development. His research group focuses on two main areas: (1) the biological roles of the crosstalk between ubiquitination and ADP-ribosylation, and (2) the molecular mechanism and biological function of non-protein ubiquitination.
Selected Publications(#co-first author, *co-corresponding author):
1. Kang Zhu*, Chatrin Chatrin, Marcin Suskiewicz, Vincent Aucagne, Dragana Ahel*, Ivan Ahel*. Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L. BioxRiv (2024)
2. Kang Zhu* , Marcin J. Suskiewicz, Chatrin Chatrin, Øyvind Strømland, Bryan W Dorsey, Vincent Aucagne, Dragana Ahel*, Ivan Ahel*. DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on nucleic acids. Nucleic Acids Res(2024)
3. Jingyu Li# , Kang Zhu# , Aihong Gu, Yiqing Zhang, Ronggui Hu, Weiguo Hu, Qun-Ying Lei, Wenyu Wen. Feedback regulation of ubiquitination and phase separation of HECT E3 ligases. PNAS (2023)
4. Kang Zhu, Marcin Suskiewicz, Andrea Hloušek-Kasun, Hervé Meudal, Andreja Mikoč, Vincent Aucagne, Dragana Ahel, Ivan Ahel. DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates.Sci. Adv(2022)
5. Kang Zhu# , Zelin Shan# , Xing Chen# , Yuqun Cai, Lei Cui, Weiyi Yao, Zhen Wang, Pan Shi, Changlin Tian,Jizhong Lou,Yunli Xie, Wenyu Wen. Allosteric Auto-inhibition and Activation of Nedd4 family E3 ligase Itch.EMBO Rep(2017)
6. Kang Zhu# , Zelin Shan# , Lu Zhang# , Wenyu Wen. Phospho-Pon Binding-Mediated Fine-Tuning of Plk1Activity. Structure(2016)
7. Pulak Kar, Chatrin Chatrin, Nina Đukić, Osamu Suyari, Marion Schuller, Kang Zhu, Evgeniia Prokhorova, Nicolas Bigot, Juraj Ahel, Jonas Damgaard Elsborg, Michael L Nielsen, Tim Clausen, Sébastien Huet, Mario Niepel, Sumana Sanyal, Dragana Ahel, Rebecca Smith, Ivan Ahel. PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation. EMBO J(2024)
8.Nina Đukić, Øyvind Strømland, Jonas Damgaard Elsborg, Deeksha Munnur, Kang Zhu, Marion Schuller,Chatrin Chatrin, Pulak Kar, Lena Duma, Osamu Suyari, Johannes Gregor Matthias Rack, Domagoj Baretić, Dorian Richard Kenneth Crudgington, Joséphine Groslambert, Gerissa Fowler, Sven Wijngaarden, Evgeniia Prokhorova, Jan Rehwinkel, Herwig Schüler, Dmitri V Filippov, Sumana Sanyal, Dragana Ahel, Michael L Nielsen, Rebecca Smith, Ivan Ahel. PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities. Sci. Adv (2023)
9.Evgeniia Prokhorova; Thomas Agnew; Anne R Wondisford; Michael Tellier; Nicole Kaminski; Danique Beijer; James Holder; Josephine Groslambert; Marcin J Suskiewicz; Kang Zhu; Julia M Reber; Sarah C Krassnig; Luca Palazzo; Shona Murphy; Michael L Nielsen; Aswin Mangerich; Dragana Ahel; Jonathan Baets; Roderick J O’Sullivan; Ivan Ahel. Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease. Mol Cell(2021)
10. Marcin J Suskiewicz, Florian Zobel, Tom E. H.Ogden, Pietro Fontana, Antonio Ariza, Ji-Chun Yang, Kang Zhu, Lily Bracken, William J.Hawthorne, Dragana Ahel, David Neuhaus, Ivan Ahel. HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation. Nature(2020)