Dr. Lihong Chen received her medical degree from Shanxi Medical University and obtained her PhD in Peking University. She has been a postdoctoral researcher and a Research Associate in the Department of Pharmacology at the University of Pennsylvania in USA from 2009 to 2016. Currently, she is a Professor in the Advanced Institute for Medical Sciences, Dalian Medical University. She is also a principal investigator in the Health Science Center at East China Normal University. She has published more than 50 scientific papers on peer-reviewed international journals such as Circulation, Science Translational Medicine, PNAS, Journal of Pineal Research, JHEP reports, and so on. Her research was supported by the Scientist Development Grant of the American Heart Association, the National 1000 Youth Talent Project of China and the National Natural Science Foundation. She has won the Outstanding Research Award of the American Heart Association and the Young Scholar Award of the International Arachidonic Acid Conference. She is now a member of the editorial board of Frontiers in Pharmacology and Scientific Reports, and serves as a reviewer of many other SCI journals including Hypertensin and Acta Pharmacologica Sinica.
Dr. Chen’s research is mainly focused on the investigation of the relationship between circadian rhythm and diseases in Cardiovascular, Metabolic, and Renal systems. She also has extensive experience in the cardiovascular biology of cyclooxygenase products and the translational pharmacology of the nonsteroidal anti-inflammatory drugs.
Representative publications
1. Jiayang Zhang, Lejia Qiu, Zhaiyi Liu, Jiaxin Liu, Bo Yu, Chengcheng Liu, Baoyin Ren, Jiaqi Zhang, Shuyao Li, Youfei Guan, Feng Zheng, Guangrui Yang#, Lihong Chen#. Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice. Journal of Pineal Research. 2024 In press.
2. Meina Guo, Shuang Ji, Hui Wang, Jiayang Zhang, Jingwen Zhu, Guangrui Yang, Lihong Chen#. Myeloid cell mPGES-1 deletion attenuates calcium phosphate-induced abdominal aortic aneurysm in male mice. Inflammation. 2024 In press.
3. Min Liu, Huixiang He, Fenling Fan, Lejia Qiu, Feng Zheng, Youfei Guan, Guangrui Yang, Lihong Chen#. Maresin-1 protects against pulmonary arterial hypertension by improving mitochondrial homeostasis through ALXR/HSP90α axis. J Mol Cell Cardiol. 2023 Aug;181:15-30.
4. Zhaiyi Liu, Jiayang Zhang, Shuyao Li, Hui Wang, Baoyin Ren, Jiazhi Li, Zhiyue Bao, Jiaxin Liu, Meina Guo, Guangrui Yang#, Lihong Chen#. Circadian control of ConA-induced acute liver injury and inflammatory response via Bmal1 regulation of Junb. JHEP Rep. 2023 Jul 22;5(11):100856.
5. Jiaxin Liu*, Shuang Ji*, Zhaiyi Liu, Meina Guo, Guangrui Yang, Lihong Chen#. Deletion of Cyclic GMP-AMP Synthase Aggravates Concanavalin A-Induced Acute Hepatic Injury by Facilitating Leukocyte Chemotaxis. Inflammation. 2023 Jun;46(3):1118-1130.
6. Chengcheng Liu, Shuyao Li, Shuang Ji, Jiayang Zhang, Feng Zheng, Youfei Guan, Guangrui Yang, Lihong Chen#. Proximal tubular Bmal1 protects against chronic kidney injury and renal fibrosis by maintaining of cellular metabolic homeostasis. Biochim Biophys Acta Mol Basis Dis. 2023 Jan 1;1869(1):166572.
7. Qing Liang*, Hu Xu*, Min Liu, Lei Qian, Jin Yan, Guangrui Yang, Lihong Chen#. Postnatal deletion of Bmal1 in cardiomyocyte promotes pressure overload induced cardiac remodeling in mice. Journal of the American Heart Association. 2022 Jul 5;11(13):e025021.
8. Jiayang Zhang, Chengcheng Liu, Qing Liang, Feng Zheng, Youfei Guan, Guangrui Yang, Lihong Chen#: Postnatal deletion of Bmal1 in mice protects against obstructive renal fibrosis via suppressing Gli2 transcription. FASEB Journal. 2021 May;35(5):e21530.
9. Lihong Chen*，Guangrui Yang*, Jiayang Zhang，Baoyin Ren，Soonyew Tang，Xuanwen Li，Garret A. FitzGerald#. Time dependent hypotensive effect of aspirin in mice. Arterioscler Thromb Vasc Biol. 2018,38(12):2819-2826.
10. Guangrui Yang*，Lihong Chen*，Gregory R. Grant Georgios Paschos，Wen-Liang Song, Erik S. Musiek，Vivian Lee，Sarah C. McLoughlin，Tilo Grosser，George Cotsarelis and Garret A. FitzGerald. Timed expression of Bmal1 influences aging and survival. Science Translational Medicine. Sci Transl Med. 2016,8(324):324ra16.
11. Lihong Chen*，Guangrui Yang，James Monslow，Leslie Todd，David P. Cormode，Jun Tang，Gregory R. Grant，Jonathan H. DeLonge，Soon Yew Tang，John A. Lawson，Ellen Pure，and Garret A. FitzGerald. Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice. Proc Natl Acad Sci. 2014,111(18): 6828-6833
12. Lihong Chen*，Guangrui Yang*，Xiufeng Xu，Gregory Grant，John A. Lawson，Mohammad Bohlooly-Y and Garret A. FitzGerald. Cell selective cardiovascular biology of microsomal prostaglandin E synthase-1. Circulation. 2013,127(2): 233-243.