Name: Xiaoming Hu
Title: Zijiang Young Scholar
Department: Health Science Center
Academic Degree: Ph.D.
Graduate School: Huazhong Agricultural University
Phone: 15900976694
Email: xmhu@hsc.ecnu.edu.cn
Address: Room 320, Experimental Building A, Health Science Center, East China Normal University
Brief Biography (including Education & Academic Background):
Dr. Xiaoming Hu works as a Zijiang Young Scholar of Health Science Center, East China Normal University (ECNU). He obtained Doctor Degree from Huazhong Agricultural University in 2015; after that, he did postdoc training at Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (2015-2017). He worked as Research Assistant Professor and Associate Professor at Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences (2017-2022), and worked as a Young Professor at Institute for Translational Brain Research, Fudan University (2022-2023). Since 2023 Dr. Hu moved to the Health Science Center at ECNU. His research interest focuses on investigating intestinal amino acid metabolic response and diseases. His works mainly published as first author (including co-first author) in journals such as Gastroenterology, Advanced Science,Journal of Crohn’s and Colitis, Endocrine Reviews, and Communications Biology. His research was supported by grants from the National Natural Science Foundation of China (NSFC), the Natural Science Foundation of Shanghai ‘science and technology innovation action plan’, and the Youth Innovation Promotion Association CAS. He has served as a reviewer for many domestic and international journals such as Nutrition and Metabolism, and Frontiers in Genetics.
Research direction: intestinal amino acid metabolic response and disease regulation
Research Interests:
1) Roles of enteroendocrine cells and secretory factors in regulating metabolism;
2) Roles of gut microbiota and their metabolites in homeostasis regulation;
3) Construction of metabolic engineering bacteria and disease regulation.
Publications (recent 5 years):
1. Niu Y#, Hu X# (co-first author), Song Y#, Wang C, Luo P, Ni S, Jiao F, Qiu J, Jiang W, Yang S, Chen J, Huang R, Jiang H, Chen S, Zhai Q, Xiao J*, Guo F*. Blautia coccoides is a newly identified bacterium increased by leucine deprivation and has a novel function in improving metabolic disorders. Advanced Science 2024 (Accept)
2. Hu X#, JiaoF#, DengJ, ZhouZ, ChenS, LiuC, LiuZ*, GuoF*. Intestinal epithelial cell-specific deletion of cytokine-inducible SH2-containing protein alleviates experimental colitis in ageing mice. Journal of Crohn’s and Colitis 2023 Aug 21;17(8):1278-1290.
3. Hu X#, Niu Y#, Luo P, Xiao F, Yuan F, Yin H, Chen S, Guo F*. Amino acid sensor GCN2 promotes SARS-CoV-2 receptor ACE2 expression in response to amino acid deprivation. Communications Biology 2022 Jul 1;5(1):651.
4. Hu X, Guo F*. Amino acid sensing in metabolic homeostasis and health. Endocrine Reviews2021 Feb;42(1):56-76. (Selected as "Featured article" by Endocrine Reviews).
5. Hu X, Deng J, Yu T, Chen S, Ge Y, Zhou Z, Guo Y, Ying H, Zhai Q, Chen Y, Yuan F, Niu Y, Shu W, Chen H, Ma C, Liu Z*, Guo F*. ATF4 deficiency promotes intestinal inflammation in mice by reducing uptake of glutamine and expression of antimicrobial peptides. Gastroenterology2019 Mar;156(4):1098-1111.
6. Yuan F#, Zhou Z#, Wu S, Jiao F, Chen L, Fang L, Yin H, Hu X, Jiang X, Liu K, Xiao F, Jiang H, Chen S, Liu Z, Shu Y, Guo F*. Intestinal activating transcription factor 4 regulates stress-related behavioral alterations via paraventricular thalamus in male mice. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2215590120.
7. Jiao F, Hu X, Yin H, Yuan F, Zhou Z, Wu W, Chen S, Liu Z*, Guo F*. Inhibition of c-Jun in AgRP neurons increases stress-induced anxiety and colitis susceptibility. Communications Biology 2023 Jan 14;6(1):50.
8. Niu Y, Jiang H, Yin H, Wang F, Hu R, Hu X, et al. Bo Peng B, Shu Y, Li Z, Chen S, Guo F*. Hepatokine ERAP1 disturbs skeletal muscle insulin sensitivity via inhibiting USP33-mediated ADRB2 deubiquitination. Diabetes 2022 May 1;71(5):921-933.
https://orcid.org/0000-0001-9661-0257