西班牙皇家科学院院士，医学与健康研究院紫江讲座教授
研究领域：表观遗传学、免疫学
1997，瓦伦西亚大学 生物科学博士
1997-2000，美国国立卫生研究院(NIH) ，博士后
2001-2008，西班牙国家癌症中心(CNIO) ，高级研究员
2008-2019，西班牙Bellvitge生物医学研究所(IDIBELL)，实验室主任
2019-今，西班牙 Josep Carreras 研究所(IJC)，实验室主任
• 特设评估员：欧洲研究委员会 (ERC)、ANEP、国家医学研究所 (INSERM)、国家癌症研究所 (INCa)、国家研究机构、荷兰科学研究组织 (NWO) ，加拿大健康研究所，英国癌症研究所。
• 西班牙教育部国家资助计划（生物医学）评估委员会成员（SAF 2009、2010、2012、2018；BFU 2017）。
Represatative Publications:
1. Ferreté-Bonastre, A.G., Martínez-Gallo, M., Morante-Palacios, O., Calvillo, C.L., Calafell-Segura, J., Rodríguez-Ubreva, J., Esteller, M., Cortés-Hernández, J., Ballestar, E. (2024) Disease activity drives divergent epigenetic and transcriptomic reprogramming of monocyte subpopulations in systemic lupus erythematosus. Annals of the Rheumatic Diseases. PMID: 38413168
Rodríguez-Ubreva, J., Calvillo, C.L., Forbes Satter, L.R., Ballestar, E. (2023) Interplay between epigenetic and genetic alterations in inborn errors of immunity. Trends in Immunology 44, 902-916.
2. Godoy-Tena, G., Barmada, A., Morante-Palacios, O., de la Calle-Fabregat, C., Martins-Ferreira, R., Ferreté-Bonastre, A.G., Ciudad, L., Ruiz-Sanmartín, A., Martínez-Gallo, M., Ferrer, R., Ruiz-Rodriguez, J.C., Rodríguez-Ubreva, J., Vento-Tormo, R., Ballestar, E. (2022) Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines. Genome Medicine 14, 134.
3. Morante-Palacios, O., Godoy-Tena, G., Calafell-Segura, J., Ciudad, L., Martínez-Cáceres, E., Sardina, J.L., Ballestar, E. (2022) Vitamin C enhances NF-kB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells. Nucleic Acids Research 50, 10981–10994.
4. Rodríguez-Ubreva, J., Arutyunyan, A., Bonder, M.J., Del Pino-Molina, L., Clark, S.J., de la Calle-Fabregat, C., Garcia-Alonso, L., Handfield, L.-F., Ciudad, L., Andrés-León, E., Krueger, F., Català-Moll, F., Rodríguez-Cortez, V.C., Polanski, K. Mamanova, L. van Dongen, S., Kiselev, V.Yu. Martínez-Saavedra, M.T., Heyn, H., Martín, J. Warnatz, K., López-Granados, E., Rodríguez-Gallego, C., Stegle, O., Kelsey, G., Vento-Tormo, R., and Ballestar, E. (2022) Single-Cell Atlas of Common Variable Immunodeficiency reveals germinal center-associated epigenetic dysregulation in B cell responses. Nature Communications 13,1779.
de la Calle-Fabregat, C., Rodríguez-Ubreva, J., Ciudad, L., Ramírez, J., Celis, R., Azuaga, A.B., Cuervo, A., Graell, E., Pérez-García, C., Díaz-Torné, C., Salvador, G., Gómez-Puerta, J.A., Haro, I., Sanmartí, R., Cañete, J.D., and Ballestar, E. (2022) The synovial and blood monocyte DNA methylomes mirror prognosis, evolution and treatment in early arthritis. JCI Insight 7, e158783.
5. Català-Moll, F., Ferreté-Bonastre, A.G., Godoy-Tena, G., Morante-Palacios, O., Ciudad, L., Barberà, L., Fondelli, F., Martínez-Cáceres, E.M., Rodríguez-Ubreva, J., Li, T., and Ballestar, E. (2022) Vitamin D receptor, STAT3 and TET2 cooperate to establish tolerogenesis. Cell Reports 38, 110244.
6. Morante-Palacios, O., Ciudad, L., Micheroli, R., de la Calle-Fabregat, C., Li, T., Barbisan, G., Houtman, M., Edalat, S.G., Frank-Bertoncelj, M., Ospelt, C., and Ballestar, E. (2022) Coordinated glucocorticoid receptor and MAFB action induces tolerogenesis and epigenome remodelling in dendritic cells. Nucleic Acids Research 50, 108-126.
7. Català-Moll, F., Ferreté-Bonastre, A.G., Li, T., Weichenhan, D., Lutsik, P., Ciudad, L., Álvarez-Prado, Á., Rodríguez-Ubreva, J., Klemann, C., Speckmann, C., Vilas-Zornoza, A., Abolhassani, H., Martínez-Gallo, M., Dieli-Crimi, R., Rivière, J., Martín-Nalda, A., Colobran, R., Soler-Palacín, P., Kracker, S., Hammarström, L., Prosper, F., Durandy, A., Grimbacher, B., Plass, C., and Ballestar, E. (2021) Activation-induced deaminase is critical for the establishment of DNA methylation patterns prior to the germinal center reaction. Nucleic Acids Research 49, 5057–5073.
8. Garcia-Gomez, A., Li, T., de la Calle-Fabregat, C., Rodríguez-Ubreva, J., Ciudad, L., Català-Moll, F., Godoy-Tena, G., Martín-Sánchez, M., San-Segundo, L., Muntión, S., Morales, X., Ortiz de Solórzano, C., Oyarzabal, J., San-José Enériz, E., Esteller, M., Agirre, X., Prosper, F., Garayoa, M. and Ballestar, E. (2021) Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease. Nature Communications 12, 421.
https://orcid.org/0000-0002-1400-2440