医学博士，副教授
教育经历：
2008年9月-2013年7月 北京大学基础医学学士
2013年9月-2016年6月 北京大学病理生理学博士
工作经历：
2016.07—2022.12 大连医科大学医学科学研究院 讲师
2023.01—2023.09 大连医科大学医学科学研究院 副教授
2023.10—今 华东师范大学医学与健康研究院 副教授
主要研究肥胖、心脏重构性疾病、血管结构异常及高血压等血管功能异常的发病机理，并寻找心血管疾病等相关治疗药物。
近5年作为负责人主持国自然等科研项目4项，作为骨干参与国家重点研发计划及国自然重点项目等科研项目5项。近年发表科研论文30余篇，其中以一作或通讯（含共同）作者身份在PNAS、JCI insight、JAHA等国际知名杂志上发表论文18篇。2018年入选辽宁省“百千万人才工程”万人层次，2019年获得大连市“青年科技之星”称号，2019年获得大连市科学技术进步奖（二等，排名3），2020年获得辽宁省教学成果奖（三等，排名12），2022年获得研究生教学成果奖（一等，排名5），第十七届中国生理学会张锡钧基金全国青年优秀生理学学术优秀口头汇报。现为中国生理学会会员、《生理学报》青年编委、全国高等学校五年制本科临床医学专业第十轮规划教材《生理学》（第10版）秘书/数字编委。
发表文章：
1. Xu H, Du S, Fang B, Li C, Jia X, Zheng S, Wang S, Li Q, Su W, Wang N, Zheng F, Chen L, Zhang X, Gustafsson JÅ, Guan Y. VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8457-8462.
2. Xu H, Fang B, Du S, Wang S, Li Q, Jia X, Bao C, Ye L, Sui X, Qian L, Luan Z, Yang G, Zheng F, Wang N, Chen L, Zhang X, Guan Y.Endothelial cell prostaglandin E2 receptor EP4 is essential for blood pressure homeostasis.JCI Insight. 2020 Jul 9;5(13):e138505
3. Xu H, Fu JL, Miao YF, Wang CJ, Han QF, Li S, Huang SZ, Du SN, Qiu YX, Yang JC, Gustafsson JÅ, Breyer RM, Zheng F, Wang NP, Zhang XY, Guan YF.Prostaglandin E2 receptor EP3 regulates both adipogenesis and lipolysis in mouse white adipose tissue.J Mol Cell Biol. 2016 Dec;8(6):518-529.
4. Xu H, Fang B, Bao C, Mao X, Zhu C, Ye L, Liu Q, Li Y, Du C, Qi H, Zhang X, Guan Y. The Prostaglandin E2 Receptor EP4 Promotes Vascular Neointimal Hyperplasia through Translational Control of Tenascin C via the cAMP/PKA/mTORC1/rpS6 Pathway.Cells. 2022 Aug 31;11(17):2720.
5. Yun W, Qian L, Yuan R, Xu H. Periplocymarin Alleviates Doxorubicin-Induced Heart Failure and Excessive Accumulation of Ceramides.Front Cardiovasc Med. 2021 Nov 19;8:732554.
6. Liang Q, Xu H, Liu M, Qian L, Yan J, Yang G, Chen L. Postnatal Deletion of Bmal1 in Cardiomyocyte Promotes Pressure Overload Induced Cardiac Remodeling in Mice.J Am Heart Assoc. 2022 Jul 5;11(13):e025021.
7. Yuan RQ, Qian L, Yun WJ, Cui XH, Lv GX, Tang WQ, Cao RC, Xu H. Cucurbitacins extracted from Cucumis melo L. (CuEC) exert a hypotensive effect via regulating vascular tone.Hypertension Research. 2019 Aug;42(8):1152-1161.
8. Yun W, Qian L, Cheng Y, Tao W, Yuan R, Xu H.Periplocymarin Plays an Efficacious Cardiotonic Role via Promoting Calcium Influx.Front Pharmacol. 2020 Aug 19;11:1292.
9. Yun W, Qian L, Yuan R, Xu H. Periplocymarin protects against myocardial fibrosis induced by β-adrenergic activation in mice.Biomed Pharmacother. 2021 Jul;139:111562.
10. Wu Y, Deng X, Ye L, Zhang W, Xu H, Zhang B. A TCF-Based Carbon Monoxide NIR-Probe without the Interference of BSA and Its Application in Living Cells. Molecules. 2022 Jun 28;27(13):4155.
11. Wang YF, Xu H, Feng L, Shen XF, Wang C, Huo XK, Tian XG, Ning J, Zhang BJ, Sun CP, Deng S.Oxidative coupling of coumarins catalyzed by laccase.Int J Biol Macromol. 2019 Aug 15;135:1028-1033.
12. Yuan R, Qian L, Xu H, Yun W. Cucurbitacins mitigate vascular neointimal hyperplasia by suppressing cyclin A2 expression and inhibiting VSMC proliferation. Animal Model Exp Med. 2024 Jul 5. doi: 10.1002/ame2.12457.
13. Qian L,Xu H, Yuan R, Yun W, Ma Y. Formononetin ameliorates isoproterenol induced cardiac fibrosis through improving mitochondrial dysfunction. Biomed Pharmacother. 2024 Jan;170:116000.
14. Ye L, Wang B, Xu H, Zhang X. The Emerging Therapeutic Role of Prostaglandin E2 Signaling in Pulmonary Hypertension. Metabolites. 2023 Nov 16;13(11):1152.
15. Yingxu Wu, Boyu Zhang, Hu Xu, Maomao He, Xiaojing Deng, Linhao Zhang, Qi Dang, Jiangli Fan, Youfei Guan, Xiaojun Peng, Wen Sun. The chronological evolution of fluorescent GPCR probes for bioimaging. Coordination Chemistry Reviews. 2023 Apr 1. DOI10.1016/j.ccr.2023.215040
16. 王赛仑，陆佳玮，管又飞，张晓燕，徐虎. 前列腺素 E2 受体 EP4 在心血管疾病中的作用.生理学报. 2019; 71(2): 361-370.
17. 徐虎，王赛仑，包成朕，叶兰，管又飞, 张晓燕.血管平滑肌细胞过表达人EP4受体改善血管紧张素II诱导的高血压.生理学报. 2021 Aug 25;73(4):597-605.
18. 徐虎,张晓燕, 管又飞. 脂质活性介质前列腺素E2与血管功能和结构重构. 中国科学:生命科学. 2022, 52(5): 646-658.
共同作者文章：
1. Su W, Peng J, Li S, Dai YB, Wang CJ, Xu H, Gao M, Ruan XZ, Gustafsson JÅ, Guan YF, Zhang XY.Liver X receptor α induces 17β-hydroxysteroid dehydrogenase-13 expression through SREBP-1c.Am J Physiol Endocrinol Metab. 2017 Apr 1;312(4):E357-E367.
2. Luan ZL, Cui XH, Xu H, Lu HY, Li YY, Lu TL, Zhang D. Association of MSI2 Gene Polymorphism with Age-at-Onset of Schizophrenia in a Chinese Population.Neurosci Bull. 2017 Dec;33(6):731-733.
3. Zhou Y, Yu J, Liu J, Cao R, Su W, Li S, Ye S, Zhu C, Zhang X, Xu H, Chen H, Zhang X, Guan Y. Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice.Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):860-870.
4. Peng J, Yu J, Xu H, Kang C, Shaul PW, Guan Y, Zhang X, Su W.Enhanced Liver Regeneration After Partial Hepatectomy in Sterol Regulatory Element-Binding Protein (SREBP)-1c-Null Mice is Associated with Increased Hepatocellular Cholesterol Availability.Cell Physiol Biochem. 2018;47(2):784-799.
5. Wang B, Zhang H, Luan Z, Xu H, Wei Y, Zhao X, Xing M, Huo X, Zhang J, Su W, Guan Y, Zhang X.Farnesoid X receptor (FXR) activation induces the antioxidant protein metallothionein 1 expression in mouse liver.Exp Cell Res. 2020 May 1;390(1):111949.
6.Ji S, Guo R, Wang J, Qian L, Liu M, Xu H, Zhang J, Guan Y, Yang G, Chen L.mPGES-1 deletion attenuates isoproterenol-induced myocardial fibrosis in mice.J Pharmacol Exp Ther. 2020 Aug 5:JPET-AR-2020-000023.
7. Liu S, Ji Y, Yao J, Zhao X, Xu H, Guan Y, Breyer RM, Sheng H, Zhu J. Knockout of the Prostaglandin E2 Receptor Subtype 3 Promotes Eccentric Cardiac Hypertrophy and Fibrosis in Mice.J Cardiovasc Pharmacol Ther. 2017 Jan;22(1):71-82.
8. Luan Z, Wei Y, Huo X, Sun X, Zhang C, Ming W, Luo Z, Du C, Li Y, Xu H, Lu H, Zheng F, Guan Y, Zhang X. Pregnane X receptor (PXR) protects against cisplatin-induced acute kidney injury in mice.Biochim Biophys Acta Mol Basis Dis. 2021 Mar 1;1867(3):165996.
9. Alam G, Luan Z, Gul A, Lu H, Zhou Y, Huo X, Li Y, Du C, Luo Z, Zhang H, Xu H, Zheng F, Guan Y, Zhang X.Activation of farnesoid X receptor (FXR) induces crystallin zeta expression in mouse medullary collecting duct cells.Pflugers Arch. 2020 Nov;472(11):1631-1641.
10. Zhang HB, Su W, Xu H, Zhang XY, Guan YF. HSD17B13: A Potential Therapeutic Target for NAFLD.Front Mol Biosci. 2022 Jan 7;8:824776.
11. Xiao P, Guo D, Yan L, Xu H, Ma Y, Liu J, Yang J, Sun W, Zhang B. A PEGylated water-soluble fluorescent and colorimetric probe for carbon monoxide detection.Analyst. 2022 May 3;147(9):1798-1802.
12. Deng X, Wu Y, Xu H, Yan J, Liu H, Zhang B.Recent research progress in galactose-based fluorescent probes for detection of biomarkers of liver diseases. Chem Commun (Camb). 2022 Oct 26.